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learn how to shut off your home’s main water supply by following these simple tips.
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june 27, 2025 – foldax inc., a leader in the development of innovative polymer heart valves, has announced compelling one-year results from the india clinical trial of the tria mitral valve, showing a good safety profile, sustained hemodynamic performance, and statistically significant improvement in patient quality of life. these are the first one-year outcomes ever presented for a multicenter clinical study of a polymer heart valve worldwide. results were presented at new york valves 2025,the annual conference organized by the cardiovascular research foundation (crf), and concurrently published in the journal of the american college of cardiology (jacc). key one-year results from the trial showed: no valve-related mortality or reinterventions >50% reduction in mean gradient (9.7 mmhg to 4.5 mmhg) and >90% increase in effective orifice area (0.9 cm² to 1.5 cm²), the highest reported in similar surgical mitral valve studies 24-point improvement in kccq score (57.5 to 81.9) and 65% increase in six-minute walk test distance (298.1 m to 494.8 m), indicating significant improvement in quality of life the prospective, multicenter trial enrolled 67 patients aged 19 to 67 across eight sites in india, with an average age of 42. notably, 64% were women, and of these, nearly half were of childbearing age, a significantly larger percentage than typically seen in clinical studies. seventy-three percent of patients had rheumatic heart disease. side view of the tria mitral valve“it is exciting to see the positive clinical outcomes associated with this novel polymer valve,” said isaac george, m.d., surgical director of the heart valve center at columbia university. “this new type of valve sets out to reimagine how a device can address clinical needs that are underserved by current valve solutions.” “i am proud to be the principal investigator in india for this groundbreaking trial and represent the highly esteemed clinical investigators who participated in the study,” said kaushal pandey, m.d., principal investigator of the tria mitral valve india clinical trial and cardiac surgeon at p.d. hinduja hospital in mumbai. “the tria mitral valve provides hope for indian patients—including younger patients and many women of childbearing age—for whom current valve options often fall short.” foldax’s vision for its novel polymer heart valves is to address the limitations of tissue and mechanical options by making its valves durable, with the future goal of avoiding a requirement for lifelong anticoagulation. tria valves incorporate a proprietary polymer—lifepolymer™ —formulated to be calcium-resistant, biostable and biocompatible. the novel polymer material enables tria valves to be robotically produced, which is designed to increase manufacturing efficiency and maximize product quality and precision. “these results validate our strategy of taking heart valve therapy to a new level by bringing innovation to a platform of products that will help patients globally,” said ken charhut, ceo of foldax. the journal of the american college of cardiology (jacc) publication can be viewed at: https://doi.org/10.1016/j.jacc.2025.06.017 for more information on the tria mitral valve and foldax, visit www.foldax.com. *note: the tria mitral valve is approved for use in india by cdsco. the tria mitral valve is for investigational use only and is not available for commercial sale in the u.s.
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learn about types of water shut-off valves for your appliances and plumbing fixtures. this guide outlines water valve types and how to find water shut-off valves.
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a plumbing system needs a main shutoff valve as well as shutoff valves for branch lines and fixtures. here's a rundown of the various types.
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to be prepared for an emergency, you should know the location of your water shutoff valve and how to use it. experts say there is more than a 60 percent chance that a major earthquake will occur in the bay area within the next 30 years. after such an event, your water supply might be unavailable for 72 hours or more.
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a water shut-off valve can prevent severe water damage when your plumbing breaks. learn how to find a water shut-off valve outside using these tips.
i initially intended to copy floodstop devices where there is a device for your dishwasher, washing machine, ice maker,etc but someone pointed out that you are better off turning off the water at your main entrance. i did some research and found several devices that will close your existing main valve, however my valve is very hard to turn so i’m sure they would not work. https://www.amazon.com/bazz-wfwsv-smart-required-google/dp/b082xgfms4 https://www.amazon.com/owfeel-control-compatible-app...
in the event of an emergency, it is important to know where your water shut-off valve is and how to stop the water flow.
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a property's main water shutoff valve is essential because it controls the flow of water throughout the home. here is how to locate your main water valve.
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a main shutoff valve is necessary for repairs, maintenance, and emergencies. learn how to find the main water shutoff valve in your home.
where is your home's main water valve, and how can you turn it off in an emergency? we explain what to look for, and which tools you might need.
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